THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 5mg

Good product . It works, capsules are tiny which are a plus. It is expensive.

Both me and my husband have the gene mutation relating to methylfolate, I have the lesser of the two and my husband has the more aggressive gene. I'm just going to give my own experience, but I can tell you in brief that this has helped my husband as well.(I started off with 1mg from the same brand, went all the way to 10mg (different brand), and am now settled at 5mg because it works just as well for me as the 10mg.)This product has helped me so much. I was already in a pretty good part of my life when taking this, but part of me wishes that maybe my life would had been different if I had this during my highschool years when I was going through depression and other mental issues (especially memory related). I've since recovered from so much through changing my diet and lifestyle alone, but now that I'm at a great place in my life this supplement actually takes it to the next level. I initially began taking these as a precaution and for general health promotion, and while taking the 10mg, one day I realized I felt pretty tired, unmotivated, and groggy. I realized that I hadn't taken my 5-MTHF that day, and have had the same experience repeated if I forget to take the 5mg dose as well. It's pretty incredible, and very noticeable when you are very busy and depend on a varied, high quality source of nutrients every day to keep you going. This is a great supplement to my nutrient-rich diet and I am confident that when it is time to begin child bearing, I will be even more thankful that this product exists.

I found out about my hardcore MTHFR mutations about 6 years ago. At first I was taking lesser brand's formulation (also 15mg) which worked for a while, but then stopped (dissolvable lozenges). I stopped taking this about 18 months ago, because I felt no different with it or not. About a month ago I bought this one and the difference is very noticeable. Rest is more restorative, detox systems work way better. Mood is not hampered by grogginess, and I can enjoy/handle more caffeine than before. Overall, a great formulation, subjectively I feel, undiluted. I plan to stick with this one as it works best out of 4 different brands I tried.

I have severe chronic fatigue and Lyme Disease, I also have the MTHFR mutation, since the genetic defect was diagnosed about 2 years ago I have tried pretty much every methyl folate product out there, my conclusion is that although expensive Thorne 5- mthf is absolutely the best supplement available to treat us mutants.My energy level and focus improves when I'm taking this, my stiffness and joint pain decreases, and my anxiety decreases.If you choose to supplement with this product it's important to start at a low dose, I would recommend starting with the 1 mg dose and gradually working your way up to the 5, you could make yourself sick otherwise as your body may not be able to handle such a big increase in folate all at once.It is also important to take a high quality B- complex supplement like Integrative Therapeutics multi B along with this as your body will need all of the other forms of vitamin B in order to properly absorb and burn methyl folate.Good Luck

I don't think it's a 5 star for me...but when rating it..one star means "I hate it", 2 I like it, 3 it's ok, you catch my drift...:)I know what I have read anyhow about MTHFR gene and that my good ol' lab states I'm one of the fortunate ones with this "Mutant" gene"..lovely word "Mutant." So, I am taking it because of the MTHFR gene issue...hoping like heck it would help with depression.However I have been on..SSRI's, SNRI's, MAOI'S anti psycotics, name the drug for depression, or augmenting with another, I've been on it. I received samples of "Deplin" which many of you already know about "Deplin but at least with my samples that I was given it was 15 mg L-methlfolate.When samples ran out..I ordered "Thorne" because (and another reason I refused to rate it low) it has historically been a very great company in my opinion. It could be me, it could be the fact I'm on so much other stuff that it's not doing what I'd love to experience like many that have said about it and/or deplin that it "helped significantly with depression"..and a biggie I hoped for I heard it helped with "motivation and energy" not I.I'm not giving up on it, not yet anyway. and I hope to submit a less pessimistic post soon. Though I've given it over three months...and to reiterate, I'm on so much stuff, that the "stuff" may be keeping 5 MTHF (3 per day) from doing the miraculous, as it has for others...I'm very happy for the "others" just on a huge "pity party" for me..because again, again and again...I hope.."this may be the one that helps me get ANYTHING accomplished.." be it crappy things or things I WANT, NEED to do...ANYTHING!So, I attempted a post in that, perhaps I can honestly say (though I have been most lengthy about it) I am not experiencing awesomeness, but perhaps a future post will say "hey, it's wonderful, hang in there any and everybody!" I hope so!